I'm calling it now, she's gonna get in a fight with Max over something very soon.

#SeriousPost

If you mean that all of her friends have been antagonistic with her at some point recently, then sure,
But if you're saying that she as a character is incapable of getting along I disagree.

Isaac is being blind and unreasonable and channeling his angsty frustration at her.

Ed thought that she disliked him in favor of Max, mostly because his spirit told him that he was being weak and foolish. She wasn't actually doing anything to him, Ed was simply projecting.

Spender was being reckless and self sacrificing, and Isabel told him so, and asked him not to feel like he was alone in the world.

It's not Isabel's fault that her friends seem to see problems where there are none. Since Max's spirit doesn't seem to repeatedly put him down and tell him how weak and/or foolish he is, and max seems to be a bit more reasonable in general, I don't think he's gonna create some problem with Isabel.

He's got too many actual problems on his plate to be inventing new ones.

I guess that's a positive side of grudges - they can't put you down or be snarky at you, since they can't really talk. They may eat you though.